Abstract：Objective To explore the risk factors affecting the occurrence of diabetic nephropathy (DN). Methods Totally 179 patients, 98 males and 81 females, with type 2 diabetes mellitus hospitalized in the People’s Hospital Affiliated to Hubei University of Medicine from June 2013 to November 2015 were selected as the research objects. According to the levels of urinary albumin excretion rate (UAER), all the patients were divided into the DN group (UAER≥20μg/min, n=85) and the non-DN group (UAER<20μg/min, n=94). We compared the basic information like sex, age, weight, height, duration of disease, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking history, drinking history and hyperlipidemia history as well as the results of laboratory tests, including total cholesterol(TC), triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), fasting blood-glucose (FPG), 2-hour plasma glucose (2hPG), fasting insulin (INS), hemoglobin ALC (HbAlc), uric acid (UA) and c-reactive protein (CRP), between the two groups. Multiple logistic aggression analysis was used to explore the risk factors of diabetic nephropathy. Results No statistically significant differences were found in the sex, body mass index (BMI), smoking history, drinking history, TC, TG, LDL-C and HDL-C between the two groups (all P>0.05). The age, duration of disease, SBP, DBP and the number of patients with hypertension history or hyperlipidemia history were significantly higher in the DN group than in the non-DN group (all P<0.05). The UAER((90.03±11.13) vs. (13.53±3.25) μg/min), FPG((10.01±1.31) vs. (7.52±1.14) mmol/L), 2hPG((12.53±2.24)vs. (9.31±1.82)mmol/L), fasting INS((15.73±3.27)vs. (12.03±3.15)mmol/L)), HbAlc((7.48±1.71)vs. (6.18±1.93)%), UA ((414.13±94.23)vs. (341.81±87.36)μmol/L)and CRP ((6.12±1.52)vs. (4.27±1.14)mg/L)were significantly higher in the DN group than in the non-DN group (all P<0.001). Multiple logistic aggression analysis showed that age (≥50 years), duration of disease(≥10 years) and complication with hypertension or hyperlipidemia, high FPG, high fasting INS, high HbAlc, high UA and high CRP were the risk factors of diabetic nephropathy. Conclusions Age (≥50 years), duration of disease (≥10 years), complication with hypertension, hyperlipidemia, high FPG, high fasting INS, high HbAlc, high UA and high CRP are risk factors of diabetic nephropathy.
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2017, Vol. 24 
