Abstract：ObjectiveTo analyze environmental risk factors of early-onset coronary heart disease in Baoan District, Shenzhen City, so as to explore intervention measures to decrease its incidence. MethodsTotally 339 patients with coronary heart disease from the People’s Hospital of Baoan District, Shenzhen were included in the study and grouped into early-onset coronary heart disease group (172 cases) and late-onset coronary heart disease group (167 cases) according to age at onset recorded in their clinical data. Having hypertension, diabetes, smoking, alcohol abuse, high total cholesterol (TC), high triglycerides (TG), high low density lipoprotein cholesterol (LDL), low high density lipoprotein cholesterol (HDL), high C-reactive protein (CRP), high uric acid (UA), and high fibrinogen (Fib) as potential environmental risk factors, Chi-square test and logistic regression analysis were used to explore risk factors of early-onset coronary heart disease and late-onset coronary heart disease. ResultsThe percentages of high TG and low HDL were significantly higher in the early-onset coronary heart disease group than those in the late-onset coronary heart disease group (χ2=12.011, P=0.001; χ2=11.208, P=0.001). So were the men proportion and smoking rate (χ2=4.849, P=0.028; χ2=5.728, P=0.017). However, the incidence of hypertension was significantly lower in the early-onset coronary heart disease group than that in the late-onset coronary heart disease group (χ2=7.654, P=0.006). Logistic regression analysis indicated that after collaborative factors were corrected, high TG and low HDL were the environmental risk factors for early-onset coronary heart disease (χ2=6.607, P=0.010; χ2=5.450, P=0.020) and complication with hypertension was a risk factor for late-onset coronary heart disease (χ2=6.702, P=0.010) ConclusionsIn the prevention of early-onset coronary heart disease, the lipid lowering therapy with lowering low density lipoprotein cholesterol as its primary goal should include lowering triglyceride level. And risk from smoking can not be ignored .
[1] 行岳真, 祁瑞, 李金梅, 等. 主成分Logistic回归在筛选冠心病危险因素中的应用[J]. 实用预防医学, 2012, 19(8):1138-1140. [2] Jiang D, Zheng D, Wang L, et al. Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females[J]. PLoS One, 2013, 8(3):e59752. [3] Huang C, Huang J, Tian Y, et al. Sugar sweetened beverages consumption and risk of coronary heart disease: A meta-analysis of prospective studies[J]. Atherosclerosis, 2014, 234(1):11-16. [4] Suh B, Shin DW, Lee SP, et al. Family history of coronary heart disease is more strongly associated with coronary than with carotid atherosclerosis in healthy asymptomatic adults[J]. Atherosclerosis, 2014, 233(2):584-589. [5] Wong ND, Shaw L, Carr J, et al. Family history of coronary heart disease and the incidence and progression of coronary artery calcification: multi-ethnic study of atherosclerosis (MESA)[J]. Atherosclerosis, 2014, 232(2):369-376. [6] Panagiotakos DB. Family history of coronary heart disease as a predictor of the incidence and progression of coronary artery calcification[J]. Atherosclerosis, 2014, 233(1):30-31. [7] Gan WQ, Davies HW, Koehoorn M, et al. Association of long-term exposure to community noise and traffic-related air pollution with coronary heart disease mortality[J]. Am J Epidemiol, 2012, 175(9):898-906. [8] 张少敏, 夏志琦, 朱蕾, 等. 冠心病患者合并代谢综合征危险因素与冠状动脉病变的关系[J]. 第三军医大学学报, 2008, 30(15):1484-1486. [9] 赵映, 田峰, 胡舜英, 等. 不同性别冠心病患者危险因素及冠状动脉病变特点分析[J]. 中华流行病学杂志, 2012, 33(4):423-427. [10] Peloso GM, Auer PL, Bis JC, et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks[J]. Am J Hum Genet, 2014, 94(2):223-232. [11] Bressler J, Folsom AR, Couper DJ, et al. Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study[J]. Am J Epidemiol, 2010, 171(1):14-23. [12] 胡大一, 丁荣晶. 《中国成人血脂异常防治指南》解读[J]. 中华内科杂志, 2008, 47(9):723-724. [13] Abdel-Maksoud MF, Eckel RH, Hamman RF, et al. Risk of coronary heart disease is associated with triglycerides and high-density lipoprotein cholesterol in women and non-high-density lipoprotein cholesterol in men[J]. J Clin Lipidol, 2012, 6(4):374-381. [14] Elis A, Pereg D, Froom P, et al. HDL-C levels and revascularization procedures in coronary heart disease patients treated with statins to target LDL-C levels[J]. Clin Cardiol, 2011, 34(9):572-576. [15] Prugger C, Wellmann J, Heidrich J, et al. Passive smoking and smoking cessation among patients with coronary heart disease across Europe: results from the EUROASPIRE III survey[J]. Eur Heart J, 2014, 35(9):590-598.
2015, Vol. 22 
