Abstract：Objective To explore the change and its clinical significance of serum and cerebrospinal fluid(CSF) interleukin-1β(IL-1β) and interleukin-1rα(IL-1ra) in Children with EV71 encephalitis. Methods According to the clinical manifestations patients were divided the ordinary patient group, severe cases group (subdivided into severe type group of severe cases and critical type group of severe cases),and the establishment of a control group. The concentration of IL-1β and IL-1ra in serum and CSF of each group were detected by double antibody sandwich ELISA method. Results Serum and CSF IL-1β,IL-1ra levels of severe cases group in the acute phase were significantly higher than those of the ordinary cases group and control group respectively(P<0.05 or P<0.01). Serum and CSF levels of IL-1β and IL-1ra in critical type group of severe cases were elevated compared with severe type group of severe cases(P<0.05 or P<0.01). Serum and CSF IL-1β and IL-1ra levels of severe cases group in the acute phase were significantly higher than those of the recovery period of severe cases group and the control group(P<0.05 or P<0.01). ConclusionsIL-1β and IL-1ra may participate in the pathogenesis of EV71 encephalitis.
陈秀丽, 周朱瑛, 李光乾, 王海萍. EV71脑炎患儿血清和脑脊液IL-1β,IL-1rα的变化及临床意义[J]. 实用预防医学, 2016, 23(2): 154-156.
CHEN Xiu-li, ZHOU Zhu-ying, LI Guang-qian, WANG Hai-ping. The significance of interleukin-1β and interleukin-1rα levels in serum and CSF of children with EV71 encephalitis. , 2016, 23(2): 154-156.
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