Abstract：Objective To explore the application value of procalcitonin in the diagnosis of bacterial infection in newborns. Methods One hundred and ten infected newborns were served as the experiment group, and 82 non-infected newborns were simultaneously considered as the control group. The levels of procalcitionin (PCT) and C-reactive protein (CRP) were compared between the two groups. Results The levels and positive rates of PCT and CRP in the severe infection group and the local infection group were all higher than those of the control group, and the levels and positive rates of PCT and CRP were higher in the severe infection group than in the local infection group, with statistically significant difference (P<0.05). No statistically significant difference was found in the levels of PCT and CRP between the Gram-positive bacteria group and the Gram-negative bacteria group (P>0.05). The sensitivity and specificity of PCT in the diagnosis of bacterial infection were 89.09% and 91.46%, respectively. The sensitivity and specificity of CRP in the diagnosis of bacterial infection were 81.82% and 90.24%, respectively. The levels of PCT and CRP of the effective treatment group decreased with the time, but the level of PCT of the ineffective treatment group increased with the time. No obvious change was found in the level of CRP. Conclusions Determination of PCT can be used for early diagnosis of bacterial infection, with high sensitivity for detection of severe infection. It is suitable for disease monitoring and medication guide in bacterial infected patients.
龚瑾, 李素萍, 刘赛红, 张娟, 汪倩. 降钙素原在新生儿细菌感染诊断中的应用价值[J]. 实用预防医学, 2016, 23(7): 870-872.
GONG Jin, LI Su-ping, LIU Sai-hong, ZHANG Juan, WANG Qian. Application value of procalcitonin in the diagnosis of neonatal bacterial infection. , 2016, 23(7): 870-872.
[1] 沈国森, 徐致远. 血清降钙素原、C反应蛋白、白细胞计数对细菌性感染的诊断价值研究[J]. 中国现代医生, 2013, 51(1):67-69. [2] Kherad O, Kaiser L, Bridevaux PO, et al. Upper-respiratory viral infection, biomarkers, and COPD exacerbations[J].Chest, 2010, 138 (4):896-904. [3] 徐静. 血清降钙素原、C反应蛋白及白细胞计数在儿童感染性疾病中的诊断价值[D].合肥:安徽医科大学, 2014. [4] Schuetz P, Albrich W, Mueller B. Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future[J].BMC Med, 2011, 9(38): 107. [5] Lee JY,Hwang SJ,Shim JW. Clinical significance of serum procalcitonin in patients with community-acquired lobar pneumonia[J]. Korean J Lab Med,2010,30(4):406-413. [6] 胡可,刘文恩,梁湘辉. 降钙素原在细菌感染中临床应用的研究 [J]. 中华医院感染学杂志,2011,21(1):30-33. [7] 高岚. 血清内毒素、C反应蛋白及降钙素原诊断细菌感染性疾病的临床研究[J]. 实用预防医学, 2014, 21(12):1510-1512. [8] Jaye DL, Waites KB. Clinical applications of C-reactive protein in pediatrics[J]. Pediatr Infect Dis J, 1997, 16(8):735-747. [9] Schuetz P, Haubitz S, Mueller B. Do sepsis biomarkers in the emergency room allow transition from bundled sepsis care to personalized patient care[J]. Curr Opin Crit Care, 2012, 18(4):341-349. [10] Cheval C, Timsit JF, Garrouste-Orgeas M, et al. Procalcitonin (PCT) is useful in predicting the bacterial origin of an acute circulatory failure in critically ill patients[J]. J Intensive Care Med, 2000, 26(2):S153-S158. [11] Ruiz-Rodríguez JC, Caballero J, Ruiz-Sanmartín A, et al. Usefulness of procalcitonin clearance as a prognostic biomarker in septic shock: a prospective pilot study[J]. Med Intensiva, 2012, 36(7):475-480.
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