Abstract：Objective To study the characteristics of dynamic changes on total bromine and N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys)in urine of employees after exposure to 1-bromopropane(1-BP). Methods We selected employees from a cleaning workshop and a control workshop of an optical glass product company, and then detected the concentration of total bromine and AcPrCys in urine of the employees before and after the shift on Monday (W1), Tuesday (W2), Thursday (W4) and Saturday (W6) in one week. The rank sum test was used for statistical analysis, and the time-concentration curve was drawn. Results In the case of exposing to 45.6 mg/m3 of 1-BP in the air of workplace, the level of total urinary bromine was 32.8-948.1 μg/L in the control group and 127.6-3,937.0 μg/L in the cleaning group. Total urinary bromine concentration before and after the shift in all above-mentioned working days between the cleaning group and the control group showed statistically significantdifferences(P>0.05) except W1 before the shift. The level of urinary AcPrCys was 4.0-12.8 μg/L in the control group and 15.0-3,823.1 μg/L in the cleaning group. There were statistically significant differences in urinary AcPrCys concentration before and after the shift in all above-mentioned working days between the cleaning group and the control group (P>0.05). The detection range of total urinary bromine concentration in the control group was wide. The cleaning group was found to have an obvious trend regarding a low level of total urinary bromine before the shift but a high level after the shift on W4 and W6, with the maximum amplitude of the two fluctuations reaching 2.9 times. The detection range of urinary AcPrCys concentration in the control group was narrow, yet fluctuated greatly, and the concentration before and after the shift was stable since W2, with the maximum amplitude of the two fluctuations reaching 1.6 times. Conclusions Total urinary bromine and AcPrCys can both reflect the metabolic characteristics of 1-BP in vivo, but urinary AcPrCys is more specific and sensitive as a biological marker of 1-BP internal exposure.
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2020, Vol. 27 
