Willingness to receive COVID-19 vaccination and its influencing factors among general population and medical staff in China
SHI Hui-lin1, WU Qian-hui1, CHEN Zhi-yuan1, GONG Hui1, YANG Juan1,2, YU Hong-jie1,2,3
1. Key Laboratory of Public Health Safety of Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China; 2. Shanghai Institute of Major Infectious Disease and Biosecurity, Shanghai 200032, China; 3. Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200032, China
Abstract：Objective To investigate the willingness to receive COVID-19 vaccines before granting market approval and its influencing factors among general population and healthcare workers in China. Methods A telephone survey and a web-based questionnaire survey on the willingness to receive COVID-19 vaccines were conducted among local residents and healthcareworkers randomly selected from three cities in east, middle and west areas of China on June 18-30, 2020, and multivariate logistic regression analysis was performed to identify its influencing factors. Results A total of 1,874 general persons and 627 medical workers participated in this study. 82.9% of the general persons and 95.9% of the healthcare workers were willing to receive COVID-19 vaccines, 83.0% of parentsto vaccinate children and 77.8% of caregivers to vaccinate the elderly. The efficacy of COVID-19 vaccines was positively correlated with vaccination intention. Multivariate logistic regression analysis showed that general population living in Shanghai (OR=0.314, 95%CI:0.209-0.464) or Wuhan (OR=0.547, 95%CI:0.354-0.836) had a lower willingness to be vaccinated against COVID-19 compared with those in Lanzhou, whereas medical workers who had ever received a flu vaccine (OR=2.784, 95%CI:1.254-6.279) were more likely to accept COVID-19 vaccination. General population and medical workers with higher risk perception of COVID-19 were more willing to have COVID-19 vaccination (ORgeneral population=2.046, 95%CI:1.685-2.495; ORmedical workers=1.843, 95%CI:1.081-3.082). The main reasons for the unwillingness to immunization were to worry about the vaccines' safety and effectiveness. Conclusion There is a high demand for and awareness of COVID-19 vaccination among the general population and healthcare workers in China, suggesting that mass vaccination campaigns that focus on the introduction of safety and effectiveness of the vaccines should be conducted so as to increase the coverage rate of COVID-19 vaccination and facilitate the early formation of population immunization barriers.
时慧琳, 吴谦惠, 陈志元, 龚慧, 杨娟, 余宏杰. 中国一般人群及医务工作者的新冠肺炎疫苗接种意愿及影响因素研究[J]. 实用预防医学, 2022, 29(6): 671-677.
SHI Hui-lin, WU Qian-hui, CHEN Zhi-yuan, GONG Hui, YANG Juan, YU Hong-jie. Willingness to receive COVID-19 vaccination and its influencing factors among general population and medical staff in China. , 2022, 29(6): 671-677.
[1] Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China [J]. N Engl J Med, 2020, 382(18):1708-1720. [2] Chen W, Wang Q, Li YQ, et al. Early containment strategies and core measures for prevention and control of novel coronavirus pneumonia in China [J]. Chinese J Prev Med, 2020, 54(3):239-244. [3] Karpiński TM, Ozarowski M, Seremak-Mrozikiewicz A, et al. The 2020 race towards SARS-CoV-2 specific vaccines [J]. Theranostics, 2021, 11(4):1690-1702. [4] Zhang J, Litvinova M, Liang Y, et al. Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China[J]. Science, 2020, 368(6498):1481-1486. [5] Wang L, Cowling BJ, Wu P, et al. Human exposure to live poultry and psychological and behavioral responses to influenza A(H7N9), China [J]. Emerg Infect Dis, 2014, 20(8):1296-1305. [6] Fu C, Wei Z,Pei S,et al. Acceptance and preference for COVID-19 vaccination in health-care workers (HCWs) [J]. MedRxiv, 2020:1-15. [7] Lin Y,Hu Z,Zhao Q,et al. Understanding COVID-19 vaccine demand and hesitancy: a nationwide online survey in China [J]. PLoS Negl Trop Dis, 2020, 14(12):e0008961. [8] Wang MW,Wen W,Wang N,et al. COVID-19 vaccination acceptance among healthcare workers and nonhealthcare workers in China: a survey[J]. Fornt Public Health, 2021, 9:709056. [9] Wang J, Jing R, Lai X, et al. Acceptance of COVID-19 vaccination during the COVID-19 pandemic in China [J]. Vaccines (Basel), 2020, 8(3):482. [10] Liu R,Zhang Y,Nicholas S,et al. COVID-19 vaccination willingness among Chinese adults under the free vaccination policy[J]. Vaccines (Basel), 2021, 9(3):292. [11] Wang Q, Yang L, Jin H, et al. Vaccination against COVID-19: a systematic review and meta-analysis of acceptability and its predictors[J]. Prev Med, 2021, 150: 106694. [12] Wang Q, Xiu S, Zhao S, et al. Vaccine hesitancy: COVID-19 and influenza vaccine willingness among parents in Wuxi, China-a cross-sectional study[J]. Vaccines (Basel), 2021, 9(4):342. [13] 赵春艳, 石晶, 张国峰, 等. 北京通州区中小学生家长为子女接种新冠疫苗意愿及影响因素 [J]. 中国学校卫生, 2021, 42(3):371-374,380. [14] Sallam M. COVID-19 vaccine hesitancy worldwide: a concise systematic review of vaccine acceptance rates[J]. Vaccines (Basel), 2021, 9(2):160. [15] Gan L, Chen Y, Hu P, et al. Willingness to receive SARS-CoV-2 vaccination and associated factors among Chinese adults: a cross sectional survey[J]. Int J Environ Res Public Health, 2021, 18(4):1993. [16] Wang C, Han B, Zhao T, et al. Vaccination willingness, vaccine hesitancy, and estimated coverage at the first round of COVID-19 vaccination in China: a national cross-sectional study[J]. Vaccine, 2021, 39(21):2833-2842. [17] Fisher KA,Bloomstone SJ,Walder J,et al. Attitudes toward a potential SARS-CoV-2 vaccine:a survey of U.S. adults [J]. Ann Intern Med, 2020, 173(12):964-973. [18] Chen MS, Li YJ, Chen JS, et al. An online survey of the attitude and willingness of Chinese adults to receive COVID-19 vaccination [J]. Hum Vacc Immunother, 2021, 17(7):2279-2288. [19] Lin C,Tu P,Beitsch LM. Confidence and receptivity for COVID-19 vaccines: a rapid systematic review[J]. Vaccines (Basel), 2020, 9(1):16. [20] 中华预防医学会.预防接种知情告知专家共识(上)[J].实用预防医学,2021,28(4):385-411. [21] Jarrett C, Wilson R, O'Leary M, et al. Strategies for addressing vaccine hesitancy-a systematic review[J]. Vaccine, 2015, 33(34):4180-4190.
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