Abstract：Objective To systematically evaluate the relationship between peripheral white blood cell (WBC) count and the risk of hypertension. Methods China National Knowledge Infrastructure, Wanfang database, Weipu database, PubMed, Embaseand the Cochrane Library were searched for epidemiological observational studies focusing on the relationship between peripheral WBC count and risk of hypertension. Two researchers independently selected the literatures based on the criteria for inclusion and exclusion, then extracted the related data and evaluated the quality of the included literatures according to the Newcastle-Ottawa Scale. A meta-analysis was performed by using Stata 12.0 software. Results A total of 10 articles were enrolled, including 11 studies (namely, 7 cohort, 1 nested case-control, 1 case-control and 2 cross-sectional studies). A total of 96,285 participants were involved, including 23,861 hypertension patients. A random effects model was used to calculate the pooled effect value. The results showed that the risk of hypertension in the group with the highest WBC count was 34% higher than that in the group with the lowest WBC count (RR=1.34, 95%CI:1.21-1.48). The risk of hypertension increased by 6% (RR=1.06, 95%CI:1.01-1.12) for every 1×109/L increase in WBC count. Conclusion The level of peripheral WBC count is associated with the risk of hypertension. The elevated WBC count may increase the risk of hypertension.
陈磊, 刘新灿, 李明, 孙天福. 外周血白细胞计数水平与高血压风险相关性的meta分析[J]. 实用预防医学, 2022, 29(3): 318-323.
CHEN Lei, LIU Xin-can, LI Ming, SUN Tian-fu. Correlation between peripheral white blood cell count and risk of hypertension: a meta-analysis. , 2022, 29(3): 318-323.
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2022, Vol. 29 
