Abstract：Objective To investigate the epidemiological features and risk factors of atopic dermatitis (AD) in preschoolers in Haikou City. Methods From October to November in 2020, a questionnaire survey and physical examination were conducted to investigate the epidemiological features of AD in preschool children aged 3-6 years in Haikou City, and logistic regression analysis was performed to identify the risk factors of AD. Results The total prevalence rate of AD in the preschool children in Haikou City was 4.79%, of which 5.20% of AD occurred in boys, 4.33% in girls, 5.65% in children aged 3-4 years and 4.10% in children aged 5-6 years. No statistically significant difference was found in the prevalence rate of AD between different genders and ages (both P>0.05). The disease severity in children with AD was mainly mildand moderate. 64.95% of the AD children had the first onset within 1 year of age, and 45.36% of the AD children accompanied with other anaphylactic diseases. Multivariate logistic regression analysis showed that parental history of allergic diseases, city residence, children with passive smoking, damp living environment, pregnant mothers and children lived in newly decorated homes were independent risk factors for AD in the preschoolers. Conclusion The prevalence rate of AD in the preschoolers aged 3-6 years in Haikou City was high, and theindependent risk factors for AD in the preschoolers were parental history of allergic diseases, city residence, children with passive smoking, damp living environment, children and pregnant mothers lived in newly decorated homes.
肖传柳, 林鸿昌, 罗杨, 崔丽霞. 海口市学龄前儿童特应性皮炎流行病学调查[J]. 实用预防医学, 2021, 28(12): 1471-1474.
XIAO Chuan-liu, LIN Hong-chang, LUO Yang, CUI Li-xia. Epidemiological survey of atopic dermatitis among preschool children in Haikou City. , 2021, 28(12): 1471-1474.
[1] Fishbein AB, Silverberg JI, Wilson EJ, et al. Update on atopic dermatitis: diagnosis, severity assessment, and treatment selection[J]. J Allergy Clin Immunol Pract, 2020, 8(1):91-101.
[2] 郝飞,张道军,钱添.成人发病型特应性皮炎:一个值得关注的新概念[J].中华皮肤科杂志,2020,53(9):747-750.
[3] 罗瑞静,刘杰,彭勇,等.上海市嘉定区儿童特应性皮炎中医证候分布规律的临床流行病学调查[J].中国皮肤性病学杂志,2019,33(8):943-948.
[4] Williams HC. Epidemiology of human atopic dermatitis-seven areas of notable progress and seven areas of notable ignorance[J].Vet Dermatol, 2013, 24(1):3-9.
[5] 顾恒,颜艳,陈崑,等.我国特应性皮炎流行病学调查[J].中华皮肤科杂志,2000,33(6):379-382.
[6] Thyssen JP, Egeberg A. Cardiovascular disease and atopic dermatitis: epidemiological strengths and limitations[J]. Br J Dermatol, 2018, 179(4):1014-1015.
[7] 陈丽萍,黄晓燕,肖易,等.我国特应性皮炎、银屑病、痤疮和荨麻疹的患病率及危险因素[J].中南大学学报(医学版),2020,45(4):449-455.
[8] Wey GD, Adefemi SA, Amao EA. Prevalence and pattern of atopic dermatitis among children aged 6 months to 14 years seen in General Out-Patient Clinic of Federal Medical Centre, Bida [J]. West Afr J Med, 2020, 37(2):124-130.
[9] 尉莉,郜玉玲,毕健平.青岛市9~10岁儿童特应性皮炎状况调查[J].青岛大学医学院学报,2016,52(6):726-727.
[10] 别国梁,朱萍,黄维平,等.280例过敏性鼻炎患者过敏原分布及影响因素分析[J].实用预防医学,2020,27(9):1096-1099.
[11] 叶惠英,韩珊珊,柯琴剑.1 252例过敏性疾病患者血清过敏原检测与分析[J].实用预防医学,2016,23(4):462-464.
[12] Hunter P. Public health struggles to square hygiene with diversity: research on the link between microbiomes and immune function puts the "hygiene hypothesis" to rest[J]. EMBO Rep, 2020, 21(10):e51540.
[13] Kronzer VL, Crowson CS, Sparks JA, et al.Investigating asthma, allergic disease, passive smoke exposure, and risk of rheumatoid arthritis[J].Arthritis Rheumatol, 2019, 71(8):1217-1224.
[14] Saito A, Tanaka H, Usuda H, et al. Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice[J]. Environ Toxicol, 2011, 26(3):224-32.
[15] Hirotsu A, Iwata Y, Tatsumi K, et al. Maternal exposure to volatile anesthetics induces IL-6 in fetal brains and affects neuronal development[J]. Eur J Pharmacol, 2019, 863(4):172682.
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