Correlation of serum levels of ITGβ1, IFI16 and TTR with the degree of progression of hypertension in pregnancy and their clinical expression significance
LI Chi-hua1, ZENG Zhong-ping2, LIU Xiu-li1, XIE Jia1, LIU Fang1, MA Yue1, TANG Yuan1, LIU Qin1
1. The Central Hospital of Panzhihua City, Panzhihua, Sichuan 617067, China; 2. Panzhihua Municipal Maternal and Child Health Care Hospital, Panzhihua, Sichuan 617000, China
Abstract：Objective To investigate the association of serum levels of integrin β1 (ITGβ1), interferon-inducible protein 16 (IFI16) and transthyretin (TTR) with the disease progression of hypertension during pregnancy and their clinical expression significance. Methods From November 2018 to January 2020, 91 patients with hypertension during pregnancywho delivered babies atthe Central Hospital of Panzhihua City were selected as the study group, and 91 normal pregnant women during the same period were randomly selected as the control group. The serum levels of ITGβ1, IFI16 and TTR of the two groups were compared.Spearsonrank correlation analysis was conducted to explore the correlation between the above-mentioned serum indexes and the disease progression of hypertension during pregnancy. The receiver operating characteristic curve was used to analyze the predictive value of serum indexes for pregnancy outcomes of the patients with hypertensive disorder of pregnancy. Results Serum levels of ITGβ1 and IFI16 were higher in the study group than in the control group, while serum level of TTR was lower in the study group than in the control group (P<0.05). The degree of progression of hypertension during pregnancy was positively correlated with serum levels of ITGβ1 and IFI16, but negatively correlated with serum level of TTR (P<0.05). The area under the curve (AUC) of serum ITGβ1>2.38 ng/ml, IFI16>24.39 ng/ml and TTR≤315.08 mg/L combined to predict the presence or absence of adverse pregnancy outcomes in the hypertensive patients during pregnancy was 0.861, which was greater than the single predicted AUC of each index (0.782, 0.813, 0.790), and the sensitivity and specificity of the combined prediction were 80.00% and 81.82%, respectively. Conclusion The expression of serum ITGβ1 and IFI16 in the patients with pregnancy-induced hypertensionincreased significantly, but the expression of serum TTR decreased, which were closely related to the occurrence and progression ofpregnancy-induced hypertension, and could assist clinical prediction of pregnancy outcomes of the patients.
李驰花, 曾仲萍, 刘秀丽, 谢佳, 刘芳, 马玥, 唐媛, 刘琴. ITGβ1、IFI16、TTR血清水平与妊娠期高血压疾病进展程度关联性及临床表达意义探究[J]. 实用预防医学, 2021, 28(6): 691-694.
LI Chi-hua, ZENG Zhong-ping, LIU Xiu-li, XIE Jia, LIU Fang, MA Yue, TANG Yuan, LIU Qin. Correlation of serum levels of ITGβ1, IFI16 and TTR with the degree of progression of hypertension in pregnancy and their clinical expression significance. , 2021, 28(6): 691-694.
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2021, Vol. 28 
