Abstract：Objective To study the relationship between dietary anti-inflammatory index (DII) and risk of chronic obstructive pulmonary disease (COPD) in middle-aged and elderly men, and to observe the effect of DII on lung function and the levels of serum inflammatory markers. Methods Using a matched case-control study design, 201 middle-aged or elderly male patients with COPD diagnosed in Haikou from August 2017 to June 2019 were selected, and 201 healthy males from a community who were matched by age (±3 years) during the same period were selected as the control group. Food frequency questionnaire was used to obtain the data regarding dietary intake in the previous year of being diagnosed with COPD (cases) or the previous year (controls). All the subjects’ DII scores were calculated, and then they were divided into three categories, the anti-inflammatory group, the intermediate group and the pro-inflammatory group. The levels of serum inflammatory markers in all the subjects were detected, and lung function test was performed. Conditional logistic regression analysis was used to analyze the odds ratios (ORs) with 95% confidence intervals (CIs) for the association between DII and the risk of COPD. Spearman partial correlation was used to analyze the correlation between DII and lung function and inflammatory index. Results The DII score was higher in the COPD group than in the control group ((1.02±0.86) vs. (0.05±0.27)), with a statistically significant difference (t=15.245, P<0.001). The results of this study showed that the higher the level of DII, the higher the risk of COPD. After controlling for confounding factors, the risk of suffering from COPD in the pro-inflammatory group was 2.13 times that of the anti-inflammatory group (OR=2.13, 95%CI:1.24, 3.67). The DII scores of the COPD patients were positively correlated with lung functionindicators (including forced expiratory volume in 1 second (FEV1), the predicted value of FEV1 and forced exhalation in 1 second/forced vital capacity(FEV1/FVC)), while the DII scores of the healthy controls were only positively correlated with FEV1. In addition, the DII scores were positively correlated with inflammatory factors (including hs-CRP, IL-6 and TNF-α) in the COPD patients and the healthy controls. Conclusion Pro-inflammatory diet is a risk factor for COPD, suggesting thattargeted effortsshould be made to change the dietary structure for the high-risk population of COPD and strengthen the education about nutrition knowledge for COPD patients so as to delay further deterioration of the disease and provide guidance for COPD prevention andtreatment.
胡孙玉, 李名兰, 闵敏, 王玉芳. 海口地区中老年男性膳食抗炎指数与慢性阻塞性肺疾病的关联研究[J]. 实用预防医学, 2021, 28(5): 563-567.
HU Sun-yu, LI Ming-lan, MIN Min, WANG Yu-fang. Correlation between dietary anti-inflammatory index and chronic obstructive pulmonary disease in middle-aged and elderly males in Haikou. , 2021, 28(5): 563-567.
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