Abstract:Objective To analyze the spatial aggregation of hemorrhagic fever with renal syndrome (HFRS) in Weifang City and to explore the seasonal epidemic characteristics of HFRS cases. Methods We collected the data regarding HFRS cases reported in Weifang City from 2005 to 2019 based on township as the unit, and described the monthly incidence and area distribution of HFRS cases. ArcGIS10.0 software was used to analyze the global spatial correlation and local spatial correlation of annual accumulative cases and seasonal incidence peaks. Results The incidence rates of HFRS in Weifang City from 2005 to 2019 were between 2.80/100,000 and 7.18/100,000, showing a downward trend on the whole. There were two cycles with high incidence of HFRS, spring-summer season (from February to August) and autumn-winter season (from September to January of the next year) in the reported cases in Weifang City. Global spatial autocorrelation analysis displayed that the Moran’s I values of annual accumulative cases and seasonal incidence peaks in Weifang City were 0.5894 and 0.6977, respectively (both P<0.001), showing a significant positive spatial correlation in the distribution. Local spatial autocorrelation analysis of the reported HFRS cases in Weifang City indicated that there were two aggregation districts with high incidence of HFRS, the junction of Qingzhou-Linqu and southern Zhucheng, and one aggregation district with low incidence of HFRS in the downtown. Conclusions Two districts with high incidence of HFRS and one district with low incidence of HFRS were found in the reported HFRS cases in Weifang City, with obvious spatial aggregation and different aggregation districts with high incidence in different epidemic seasons.