Abstract：Objective To explore the effect of early administration of caffeine citrate in very low-birth weight (VLBW)newborns. Methods We retrospectively analyzed 100 VLBW newborns born in Hunan Provincial Maternal and Child Health Care Hospital and received treatment in the neonatal department between January 2018 and December 2019, and all of the cases met the inclusion criteria. According to the different treatment methods, they were divided into the observation group (n=54) and the control group (n=46). The observation group was treated intravenously with caffeine citrate within 2 hours after birth, while the control group was not given the drug immediately after birth, and caffeine citrate was administered when invasive ventilatorwas removed. The two groups were compared in terms of the incidence rate of apnea of premature (AOP) within 72 hours after extubation, duration of mechanical ventilation, duration of oxygen therapy, time of regaining birth weight, length of hospitalization and the incidence rate of complications. Results The incidence rate of AOP, duration of mechanical ventilation, duration of oxygen inhalation and length of hospitalization were all significantly lower in the observation group than in the control group, showing statistically significant differences (all P<0.05). No statistically significant difference was found in the time of regaining birth weight between the two groups (P=0.423). The incidence rate of bronchopulmonary dysplasia (BPD) was slightly lower in the observation group than in the control group, with a statistically significant difference (P=0.029). No statistically significant differences were observed in the incidence rates of feeding intolerance, hyperglycemia, neonatal necrotizing enterocolitis (NEC), grades III-IV periventricular-intraventricular hemorrhage (PVH-IVH) and retinopathy of prematurity (ROP) between the two groups (all P>0.05). Conclusions Early administration of caffeine citrate can effectively shorten the duration of mechanical ventilation and duration of oxygen therapy for VLBW newborns, and thereby reduce the length of hospitalization and decrease the incidence rate of BPD. Early administration of caffeine citrate has a good clinical effect, it is of great significance to the clinical recovery of VLBW newborns and is worth promoting.
李素萍, 汪倩, 龚瑾, 张娟. 早期使用枸橼酸咖啡因对极低出生体重儿的影响[J]. 实用预防医学, 2020, 27(12): 1446-1449.
LI Su-ping, WANG Qian, GONG Jin, ZHANG Juan. Effect of early administration of caffeine citrate in very low-birth weight newborns. , 2020, 27(12): 1446-1449.
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