Abstract：Objective To investigate the characteristics of subtypes of human papillomavirus (HPV) infection among men in Hebei region. Methods Flow-through hybridization and gene chip technique was used to determine the 21 HPV-DNA subtypes in secretion specimens of 835 male outpatients in Department of Dermatology, Hebei Provincial People’s Hospital from April, 2014 to August, 2017. Results Among the 835 outpatients, the positive rate of HPV was 24.79%(207/835), and the infection rates of single HPV subtype, two HPV subtypes, three HPV subtypes, four HPV subtypes and five HPV subtypes were 18.20% (152/835), 4.91% (41/835), 0.84% (7/835), 0.72% (6/835) and 0.12% (1/835) respectively. The detection rates of high-risk and low-risk HPV were 14.61% (122/835) and 6.35% (53/835) respectively, and the detection rate of co-infection with high-risk and low-risk HPV was 3.83% (32/835). The top five detection rates were HPV16, HPV11, HPV6, HPV58 and HPV52. In the same age group, the HPV infection pattern was dominated by single infection, and no statistically significant difference was found in the HPV infection rate among different age groups(χ2=4.677, P=0.322). Conclusions The majority of HPV subtypes detected in male urethra in Hebei region are HPV16, HPV 11, HPV6, HPV 58 and HPV 52, which provide the data for studying the epidemiological characteristics of male HPV infection.
[1] de Sanjosé S, Brotons M, Pavón MA.The natural history of human papillomavirus infection[J].Best Pract Res Clin Obstet Gynaecol,2017,47:2-13. [2] Berti FCB,Pereira APL,Cebinelli GCM,et al.The role of interleukin 10 in human papilloma virus infection and progression to cervical carcinoma[J].Cytokine Growth Factor Rev,2017,34:1-13. [3] Serrano B, Brotons M, Bosch FX, et al.Epidemiology and burden of HPV-related disease[J].Best Pract Res Clin Obstet Gynaecol,2017,47:14-26. [4] Small W, Bacon MA, Bajaj A, et al.Cervical cancer: a global health crisis [J].Cancer,2017,123(13):2404-2412. [5] 田欣欣,王睿,姜玲波,等.山东地区1 225例男性尖锐湿疣患者HPV感染亚型分析[J].中国男科学杂志,2016,30(1):41-45. [6] 吴锐浩,周星星,周武,等.温州地区门诊男性就诊者人乳头瘤病毒基因型别分析[J].中国男科学杂志,2016,22(11):1053-1055. [7] 莫和国,陈荣忠,邓文成,等.1 305例外生殖器人乳头瘤病毒基因型特征分析[J].实用预防医学,2018,25(6):726-734. [8] 王建,李文静,徐红星,等.苏州地区门诊男性患者高危型人乳头瘤病毒基因型分析[J].国际检验医学杂志,2017,38(22):3085-3087. [9] 莫和国,黄健云,黎泳仪,等.男性尿道人乳头状瘤病毒感染调查与基因亚型分析[J].中华医院感染学杂志,2015,25(13):2957-2978. [10] 韩伟,刘文康,翟卫斌,等.西安地区男性尿道感染人乳头瘤病毒基因亚型分析[J].现代检验医学杂志,2017,32(1):52-55. [11] Sabeena S, Bhat PV, Kamath V,et al.Global human papillomavirus vaccine implementation: an update[J].J Obstet Gynaecol Res,2018,44(6):989-997. [12] Lin J,Chen L, Qiu X,et al.Traditional Chinese medicine for human papillomavirus (HPV) infections: a systematic review[J].Biosci Trends,2017,11(3):267-273. [13] 杨爱琴,卞坤鹏,翟伟,等.南阳地区 227 例尖锐湿疣患者 HPV 基因型、流行病学特征及转归情况[J].实用预防医学,2018,25(9):1102-1104. [14] Markowitz LE, Gee J, Chesson H, et al.Ten years of human papillomavirus vaccination in the United States[J].Acad Pediatr,2018,18(2S):S3-S10.
2019, Vol. 26 
