髓过氧化物酶指数在急性早幼粒细胞白血病诊断中的应用评价

doi:10.3969/j.issn.1006-3110.2019.04.009

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摘要目的探讨髓过氧化物酶指数(myeloperoxidase index,MPXI)在急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)中的诊断价值。方法选取2016年1月-2018年6月于湖南省人民医院首诊为急性早幼粒细胞白血病病例(APL)50例、急性单核细胞白血病病例(acute monocytic leukemia,AMOL)50例和未发现急性早幼粒细胞白血病及急性单核细胞白血病者50例,检测其髓过氧化物酶指数、纤维蛋白(原)降解产物以及D二聚体水平,将所得数据进行统计学分析。结果急性早幼粒细胞白血病组明显高于急性单核细胞和阴性对照组(P<0.001);受试者工作特征曲线分析,MPXI、纤维蛋白(原)降解产物以及D二聚体在区分APL组和对照组的曲线下面积分别为0.936、0.841和0.773。以11.35为诊断界值点时,MPXI诊断APL的灵敏度为84.6%,特异度为97.2%。结论 MPXI在急性早幼粒细胞白血病的早期诊断中有重要意义。

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	张晓
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关键词 ：急性早幼粒细胞白血病, 髓过氧化物酶指数, 纤维蛋白原, D二聚体, 肿瘤标记物

Abstract：Objective To explore the diagnostic value of myeloperoxidase index (MPXI) in acute promyelocytic leukemia (APL). Methods Fifty patients initially diagnosed with APL, 50 patients initially diagnosed with acute monocytic leukemia (AMOL) and 50 patients without APL and AMOL were selected in the People’s Hospital of Hunan Province from January 2016 and June 2018. The levels of myeloperoxidase, fibrinogen and D-Dimer were measured, and then the result data were statistically analyzed. Results The myeloperoxidase level was significantly higher in the APL group than in the AMOL group and the negative control group (P<0.001). Receiver operating characteristic curve analysis showed that the areas under the curves for MPXI, fibrinogen and D-Dimer were 0.936, 0.841 and 0.773 respectively. When the cut-off point was determined at 11.35, the sensitivity and specificity of MPXI for the diagnosis of APL were 84.6% and 97.2% respectively. Conclusion MPXI provides valuable clinical information for early diagnosis of APL.

Key words： acute promyelocytic leukemia myeloperoxidase index fibrinogen D-Dimer tumor marker

收稿日期: 2018-07-17

R733.7

基金资助:湖南省科技厅科研课题(2017SK50521)

通讯作者: 谭黎明,E-mail:tanliming838@163.com。

作者简介: 张晓(1993-),女,湖南人,研究生,检验师,主要从事临床检验诊断工作。

引用本文:

张晓, 谭黎明, 李建英, 毛玉环. 髓过氧化物酶指数在急性早幼粒细胞白血病诊断中的应用评价[J]. 实用预防医学, 2019, 26(4): 416-419. ZHANG Xiao, TAN Li-ming, LI Jian-ying, MAO Yu-huan. Evaluation on application of myeloperoxidase index to diagnosing acute promyelocytic leukemia. , 2019, 26(4): 416-419.

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https://www.syyfyx.com/CN/10.3969/j.issn.1006-3110.2019.04.009 或 https://www.syyfyx.com/CN/Y2019/V26/I4/416

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