Relationship between the daily total intake of fluoride andserum osteocalcin in adults and its benchmark dose
LIU Bo1, TU Qing-yun2, ZHANG Ming-fang1, LIU Kang1, XIANG Quan-yong3
1.Sihong County Center for Disease Control and Prevention, Sihong, Jiangsu 223900, China; 2.School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China; 3.Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China
Abstract：Objective To explore the dose-response relationship between total fluoride intake and serum osteocalcin and the benchmark dose (BMD) of total fluoride intake so as to provide references for prevention and control of endemic skeletal fluorosis and revision of the national standard for total fluoride intake. Methods Wamiao and Xinhuai villages were selected as the investigation sites. Based on the fluoride concentration in drinking water in the household hand-pressed wells, a stratified random sampling method was used to recruit 103 adult permanent residents from Wamiao village and 43 from Xinhuai village. The surveyed contents included fluoride concentration in drinking water and food, daily intake of various foods and drinking water, and detection of fluoride in indoor and outdoor air and serum osteocalcin level. The daily total fluoride intake was calculated, and then all the subjects were divided into four groups (including groups A, B, C and D with the total fluoride intake≤1.16 mg/(person·day), >1.16 mg/(person·day), >3.48 mg/(person·day) and >4.99 mg/(person·day) respectively) according to the daily total fluoride intake. The serum osteocalcin level and the abnormal rate of serum osteocalcin in each group were statistically analyzed. Results The total fluoride intake and serum osteocalcin in the residents of Wamiao village were significantly higher than those in the residents of Xinhuai village (both P<0.01). Serum osteocalcin level and the abnormal rate of serum osteocalcin gradually increased with the increment of total fluoride intake. There was a significant dose-response relationship between the total fluoride intake and serum osteocalcin, serum osteocalcin abnormal rate. The BMD and the benchmark dose lower limitation (BMDL) of total fluoride intake calculated based on the abnormal rate of serum osteocalcin were 1.00 mg/(person·day) and 0.67 mg/(person·day) respectively. Conclusions Osteocalcin may be a sensitive indicator for early screening of bone injury in people exposed to fluoride. The BMDL of total fluoride intake calculated according to osteocalcin is significantly lower than that of the national standard.
刘伯, 涂青云, 张明访, 刘康, 向全永. 总摄氟量与成人血清骨钙素的相关关系及其基准剂量[J]. 实用预防医学, 2019, 26(3): 257-260.
LIU Bo, TU Qing-yun, ZHANG Ming-fang, LIU Kang, XIANG Quan-yong. Relationship between the daily total intake of fluoride andserum osteocalcin in adults and its benchmark dose. , 2019, 26(3): 257-260.
2019, Vol. 26 
