Abstract:Objective To analyze the epidemiological characteristics of hand, foot, and mouth disease (HFMD) in Baoshan District of Shanghai from 2015 to 2016, to explore its epidemic changing patterns, and to provide a scientific basis for formulating prevention and control strategies. Methods Hierarchy clustering method was employed to analyze the data regarding HFMD incidence and etiology in Baoshan District during 2015-2016. Results A total of 9,475 HFMD cases were reported in Baoshan District from 2015 to 2016, with the average incidence rate being 236.41/100,000. Number of cases in different months, number of cases in different age groups, incidence rates in different streets/towns and reported number of clusters of epidemic were gathered into 3 categories. HFMD had an epidemic peak during May and July (44.16%).The incidence rate was found to be the highest in the age groups of 1-4 years (73.73%).Towns as Gucun, Yanghang and Luodian had the highest incidence rate. The maximum reported cluseters of epidemic appeared in May-June, andcoxasckievirus A6(CoxA6) was the dominant pathogen of HFMD in 2015-2016. Conclusions HFMD was highly endemic in Baoshan District of Shanghai City from 2015 to 2016, and its epidemiological characteristics showed differences in time, region and population. The dominant pathogen was CoxA6. It is necessary to take targeted prevention and control strategies and countermeasures.