自身免疫性慢性荨麻疹患者外周血淋巴细胞的检测及意义
刘军连, 王晓菲, 徐冰心, 尹萌萌, 陈娓, 司少艳
中国人民解放军第306医院,北京 100101
Detection of lymphocyte subsets in peripheral blood of patients with autoimmunechronic urticaria and its significance
LIU Jun-lian, WANG Xiao-fei, XU Bing-xin, YIN Meng-meng, CHEN Wei, SI Shao-yan
The 306th Hospital of PLA, Beijing 100101, China
摘要 目的 检测自身免疫性慢性荨麻疹(AIU)患者外周血淋巴细胞亚群的分布,探讨AIU的发病机制。 方法 采用流式细胞术检测AIU患者30例与正常对照组30例外周血B、T淋巴细胞及其亚群的构成比。 结果 与正常对照组相比,AIU患者外周血B淋巴细胞构成比下降[(11.95±3.73)% vs. (14.85±4.52)%,P< 0.05];CD8+ T细胞构成比升高[(30.20±9.12) vs. (23.70±6.51)%,P< 0.05],CD4+ /CD8+ T细胞比值降低[(1.10±0.42) vs. (1.48±0.49)%,P< 0.05];T淋巴细胞和CD4+ T细胞构成比无明显变化(P> 0.05)。 结论 AIU患者B淋巴细胞和CD8+ T细胞构成比异常,CD4+ /CD8+ T细胞比例失衡,可能在AIU的发病中起作用。
关键词 :
自身免疫性慢性荨麻疹 ,
淋巴细胞 ,
细胞亚群 ,
致病机理
Abstract :Objective To detect the ratio of lymphocyte subsets in peripheral blood of patients with autoimmune chronic urticaria (AIU), and to explore the immunology mechanism of AIU. Methods Flow cytometry was used to detect the constituent ratios of B lymphocyte, T lymphocyte and their subsets in peripheral blood of 30 AIU patients and 30 healthy controls. Results As compared with the control group, the ratio of CD8+ T lymphocyte subsets ((30.20±9.12) vs. (23.70±6.51)%)in the peripheral blood of AIU patients increased (P <0.05), but the ratios of B lymphocyte((11 .95±3.73) vs. (14.85±4.52)%) and CD4+ /CD8+ T lymphocyte subsets((1.10±0.42) vs. (1.48±0.49)%) decreased (P <0.05). No obvious changes were observed in the constituent ratios of T lymphocyte and CD4+ T lymphocyte subsets in the patients with AIU. Conclusions AIU patients’ abnormal constituent ratios of B lymphocyte and CD8+ T lymphocyte subsets and the imbalance of CD4+ /CD8+ T lymphocyte subsets may play roles in the pathogenesis of AIU.
Key words :
autoimmune chronic urticaria
lymphocyte
lymphocyte subset
pathogenesis
收稿日期: 2016-10-18
基金资助: 国家自然科学基金(30872284、81071402)
通讯作者:
司少艳,E-mail:sishy306@sohu.com。
作者简介 : 刘军连(1968-),男,山东成武县人,硕士,主任医师,研究方向:皮肤免疫学和性病学。刘军连和王晓菲在本项工作中具有同等贡献,为并列第一作者。
引用本文:
刘军连, 王晓菲, 徐冰心, 尹萌萌, 陈娓, 司少艳. 自身免疫性慢性荨麻疹患者外周血淋巴细胞的检测及意义[J]. 实用预防医学, 2017, 24(2): 145-147.
LIU Jun-lian, WANG Xiao-fei, XU Bing-xin, YIN Meng-meng, CHEN Wei, SI Shao-yan. Detection of lymphocyte subsets in peripheral blood of patients with autoimmunechronic urticaria and its significance. , 2017, 24(2): 145-147.
链接本文:
https://www.syyfyx.com/CN/10.3969/j.issn.1006-3110.2017.02.005 或 https://www.syyfyx.com/CN/Y2017/V24/I2/145
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